Weight Gain: Causes, Medications, and How Hormones Affect Your Body
When you notice unexplained weight gain, a persistent increase in body mass not tied to overeating or lack of exercise. Also known as unintentional weight gain, it often signals something deeper than just calories in versus calories out. Many people assume it’s laziness or poor diet—but that’s not always the case. Sometimes it’s your hormones, your meds, or even how your body holds onto water.
Hormonal weight gain, a type of weight gain driven by imbalances in hormones like estrogen, cortisol, or thyroid hormones is common but rarely talked about. For example, fluid retention, the buildup of excess fluid in tissues that causes swelling and temporary weight increase can make you feel heavier without adding fat. It’s linked to things like birth control, menopause, or even certain antidepressants. If you’ve gained weight since starting sertraline or trazodone, you’re not alone—these meds can slow metabolism or increase appetite. Same goes for corticosteroids like clobetasol, which can cause water retention and fat redistribution. Even low-dose estrogen therapy, like in Conjubrook, can shift where your body stores fat.
And it’s not just about what you take—it’s about how your body responds. Some people gain weight on the same dose that others don’t. Genetics, stress, sleep quality, and even gut health play a part. If you’re trying to lose weight but keep hitting walls, the issue might not be willpower. It could be your thyroid, your insulin levels, or an interaction between your meds and your biology. That’s why looking at weight gain as a symptom—not a failure—is the first step to fixing it.
Below, you’ll find real, practical guides from people who’ve been there. From how desogestrel affects fertility and weight to why fluid retention spikes with estrogen, and how antidepressants like sertraline or trazodone change your metabolism—you’ll see patterns, not just pills. No fluff. No guesswork. Just clear connections between what you’re taking and what your body is doing.
- 28/Oct/2025
- by William Womack
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digoxin
weight gain
heart failure
fluid retention
medication side effects
Digoxin and Weight Gain: What You Need to Know
Digoxin doesn't cause fat gain, but it can lead to fluid retention in heart failure patients, resulting in rapid weight gain. Learn how to tell if it's water weight, what to do, and when to call your doctor.
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